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Description

In the Phase 3 GAIA (CLL13) clinical trial,58 patients with CLL who were fit and had no TP53 gene abnormalities were randomized in a 1:1:1 ratio to receive six cycles of chemotherapy: one to six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab or venetoclax-obinutuzumab-ibrutinib

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doi:10.1111/acer.13108

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CXCR1 and CXCR2, Chemokine receptors

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[0529] In certain embodiment, the transmembrane domain of the CAR comprises a CD8 transmembrane domain

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To establish a DTXresistant subline, a multiphase stepwise selection protocol was applied over an 8week period

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